Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GPR183 | P32249 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107008 | 0.92 | SLC6A7 (0.45) | HSD11B1MEN1KMT2ASLC6A7HDAC3 | |
| SCHEMBL3227694 | 0.90 | CYP3A4 (0.50) | MEN1KMT2AUSP2CYP3A4SMN1; SMN2 | |
| SCHEMBL3110208 | 0.89 | HSP90AA1 (0.47) | HSD11B1MEN1KMT2ASLC6A7HDAC3 | |
| SCHEMBL3092530 | 0.85 | CYP3A4 (0.46) | SLC6A7USP2CYP3A4SMN1; SMN2MAPK1 | |
| SCHEMBL3092695 | 0.84 | FASN (0.44) | HSD11B1MEN1KMT2ASLC6A7HDAC3 | |
| SCHEMBL3106971 | 0.77 | PTPN1 (0.45) | HSD11B1MEN1KMT2ASLC6A7HDAC3 | |
| SCHEMBL379371 | 0.74 | OPRM1 (0.67) | MEN1KMT2ASLC6A7HTTOPRM1 | |
| SCHEMBL378380 | 0.74 | SLC6A7 (0.54) | HSD11B1MEN1KMT2ASLC6A7CYP3A4 | |
| SCHEMBL3107003 | 0.72 | PTPN1 (0.50) | HSD11B1MEN1KMT2ASLC6A7HDAC1 | |
| SCHEMBL7909257 | 0.71 | PTPN1 (0.46) | HSD11B1MEN1KMT2ASLC6A7HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324250-B2 | Piperidine derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256126-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HTR3A, OPRL1, OPRK1 | HSD11B1 3638/4885MEN1 4869/4885KMT2A 1488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.