Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.46 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482163 | 0.88 | KMT2A (0.70) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30978305 | 0.82 | BTK (0.48) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28807050 | 0.80 | NPC1 (0.60) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4481678 | 0.80 | HPGDS (0.51) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL30132085 | 0.80 | HPGDS (0.51) | NPC1RAB9AMEN1KMT2ABTK | |
| SCHEMBL2710344 | 0.80 | KMT2A (0.77) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2413147 | 0.79 | EPHX2 (1.00) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14764217 | 0.79 | EPHX2 (0.68) | EPHX2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2190049 | 0.78 | ALKBH2 (0.74) | NPC1RAB9AMEN1KMT2AHPGDS | |
| SCHEMBL28876225 | 0.77 | BTK (0.41) | EPHX2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |
| US-8278337-B2 | Substituted pyridines that are JNK inhibitors | MERCK SHARP & DOHME (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100179141-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-07-15 | — | — | US | disclosed |
| EP-2132178-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179141-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK5, MAPK15 | EPHX2 2332/4885NPC1 692/4885RAB9A 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.