Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3107063 | 0.77 | EPHX2 (0.64) | BTKHPGDSALKBH2NPC1MEN1 | |
| SCHEMBL27142132 | 0.77 | PTGS2 (0.43) | RXRAGRIN1GRIN2BARLOXL2 | |
| SCHEMBL31755983 | 0.76 | RXRA (0.48) | PARP1GRM2RXRAGRIN1GRIN2B | |
| SCHEMBL27136757 | 0.76 | RXRA (0.53) | RXRAGRIN1GRIN2BARNPC1 | |
| SCHEMBL27147409 | 0.76 | RXRA (0.42) | PARP1GRM2RXRAGRIN1GRIN2B | |
| SCHEMBL23803912 | 0.75 | GPR52 (0.54) | BTK | |
| SCHEMBL30152171 | 0.75 | GPR52 (0.54) | BTK | |
| SCHEMBL29427234 | 0.75 | LOXL2 (0.49) | SYKLOXL2 | |
| SCHEMBL4043325 | 0.75 | LOXL2 (0.49) | SYKLOXL2 | |
| SCHEMBL27137469 | 0.75 | RXRA (0.41) | RXRAGRIN1GRIN2BAREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4199908-A1 | AMORPHOUS FORM OF A MALT1 INHIBITOR AND FORMULATIONS THEREOF | JANSSEN Pharmaceutica NV (BE) | 2023-06-28 | — | — | EP | claimed |
| CN-112601747-B | Pyrazole derivatives as MALT1 inhibitors | 詹森药业有限公司 | 2023-02-21 | — | — | CN | claimed |
| WO-2022038252-A1 | AMORPHOUS FORM OF A MALT1 INHIBITOR AND FORMULATIONS THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2022-02-24 | — | — | WO | claimed |
| CN-110214136-A | Pyrazole derivatives as MALT1 inhibitor | 詹森药业有限公司 | 2019-09-06 | — | — | CN | disclosed |