Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11570967 | 0.91 | ALDH3A1 (0.59) | ALDH3A1HCAR3CYP3A4MAPK1TDP1 | |
| SCHEMBL9011356 | 0.84 | MAPT (0.48) | HCAR3VCAM1KCNH2MAPTTXNRD1 | |
| SCHEMBL7174989 | 0.80 | MAPT (0.38) | ALDH3A1HCAR3VCAM1KCNH2CYP3A4 | |
| SCHEMBL8165221 | 0.79 | TP53 (0.47) | HCAR3VCAM1BCHEACHEALDH1A1 | |
| SCHEMBL7567118 | 0.78 | ALDH3A1 (0.53) | ALDH3A1HCAR3VCAM1KCNH2CYP3A4 | |
| SCHEMBL4365845 | 0.77 | ALDH3A1 (0.57) | ALDH3A1HCAR3MAPK1TDP1TSHR | |
| SCHEMBL414469 | 0.77 | ALDH3A1 (0.51) | ALDH3A1HCAR3VCAM1CYP3A4MAPK1 | |
| SCHEMBL9798892 | 0.77 | KCNH2 (0.47) | KCNH2MAPTALDH1A1TP53KMT2A | |
| Hexane SCHEMBL27460259 | 0.77 | HSD17B10 (0.56) | TDP1TSHRMAPTHSD17B10ALDH1A1 | |
| SCHEMBL27758107 | 0.76 | MAPT (0.42) | ALDH3A1HCAR3VCAM1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946302-B2 | Selective sigma-1 receptor ligands | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20130102571-A1 | SELECTIVE SIGMA-1 RECEPTOR LIGANDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-04-25 | — | — | US | disclosed |
| US-8349898-B2 | Sigma-1 receptor ligands and methods of use | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-01-08 | — | — | US | disclosed |
| US-20100179111-A1 | SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE | WARF - WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179111-A1 | SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE | SIGMAR1, OPRL1, OPRK1 | ALDH3A1 2231/4885HCAR3 204/4885VCAM1 394/4885 |
| US-20130102571-A1 | SELECTIVE SIGMA-1 RECEPTOR LIGANDS | SIGMAR1, OPRL1, OPRK1 | ALDH3A1 2266/4885HCAR3 197/4885VCAM1 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.