Sugi Predict

Sugi Predict / Compounds / SCHEMBL3107550

SCHEMBL3107550

SCHEMBL3107550

COC(=O)c1csc(N)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.46
▸ MAPT P10636 7/20 0.46
▸ HSD17B10 Q99714 7/20 0.46
▸ KDM4E B2RXH2 5/20 0.46
▸ HPGD P15428 5/20 0.46
▸ GAA P10253 2/20 0.46
▸ GLA P06280 1/20 0.46
▸ CASP1 P29466 1/20 0.46
▸ CASP7 P55210 1/20 0.46
▸ ATM Q13315 1/20 0.46
▸ CA12 O43570 3/20 0.45
▸ CA1 P00915 3/20 0.45
▸ CA2 P00918 3/20 0.45
▸ CA7 P43166 3/20 0.45
▸ CA9 Q16790 3/20 0.45
▸ CA14 Q9ULX7 3/20 0.45
▸ LMNA P02545 5/20 0.44
▸ XDH P47989 2/20 0.44
▸ TDP1 Q9NUW8 2/20 0.44
▸ L3MBTL1 Q9Y468 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5025168 0.79 LMNA (0.53) ALDH1A1MAPTHSD17B10HPGDGAA
SCHEMBL29473506 0.79 CA1 (0.48) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL70248 0.78 CA1 (0.47) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL7372827 0.78 DAO (0.61) ALDH1A1KDM4EHPGDGAAATM
SCHEMBL15057183 0.76 CA1 (0.45) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL7892513 0.76 DAO (0.53) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL365156 0.76 CA1 (0.45) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL19127835 0.76 DAO (0.59) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL31087127 0.76 CA1 (0.45) ALDH1A1MAPTHSD17B10KDM4EHPGD
SCHEMBL16289929 0.76 CA1 (0.45) ALDH1A1MAPTHSD17B10KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109400595-B Anticancer compound containing thiophene ring 深圳市第二人民医院 2020-07-17 — — CN claimed
CN-109400595-A Anticancer compound of the one kind containing thiphene ring 深圳市第二人民医院 2019-03-01 — — CN claimed
US-12415793-B2 Modulators of TMEM16A for treating respiratory disease TMEM16A LIMITED (GB) 2025-09-16 — — US disclosed
US-20250243188-A1 METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. 2025-07-31 — — US disclosed
CN-114269433-B Modulators of TMEM16A for the treatment of respiratory diseases TMEM16A有限公司 2024-08-02 — — CN disclosed
US-20230399312-A1 SUBSTITUTED PYRIMIDINES AND METHODS OF USE THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-12-14 — — US disclosed
US-20230399312-A1 SUBSTITUTED PYRIMIDINES AND METHODS OF USE THERAVANCE BIOPHARMA R&D IP LLC (US) 2023-12-14 — — US disclosed
WO-2023196985-A1 METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. (US) 2023-10-12 — — WO disclosed
WO-2023196985-A1 METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS IDEAYA BIOSCIENCES, INC. (US) 2023-10-12 — — WO disclosed
US-11673879-B2 Substituted pyrimidines and methods of use THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-06-13 — — US disclosed
US-11673879-B2 Substituted pyrimidines and methods of use THERAVANCE BIOPHARMA R&D IP, LLC (US) 2023-06-13 — — US disclosed
WO-2008156614-A2 IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS SCHERING CORPORATION (US) 2008-12-24 — — WO disclosed
US-20080161302-A1 N-(2-Methoxy-phenyl)-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide; antifungal agents; inhibiting Aspergillus F2G LTD. (GB) 2008-07-03 — — US disclosed
EP-1888063-A1 ANTIFUNGAL AGENTS F2G Ltd. (GB) 2008-02-20 — — EP disclosed
US-20070010537-A1 Fused pyramidine derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-11 — — US disclosed
WO-2006123145-A1 ANTIFUNGAL AGENTS F2G LTD (GB) 2006-11-23 — — WO disclosed
EP-1657238-A1 FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2006-05-17 — — EP disclosed
US-5814629-A FUNGICIDES, BACTERICIDES AND VIRICIDES OF PLANTS NOVARTIS FINANCE CORPORATION (US) 1998-09-29 — — US disclosed
US-5498755-A IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS ALLERGAN, INC. 1996-03-12 — — US disclosed
WO-1996006070-A1 DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY ALLERGAN (US) 1996-02-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250243188-A1 METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS MAT2A, MAT2B, MAT1A ALDH1A1 140/4885MAPT 1876/4885HSD17B10 1920/4885
US-12415793-B2 Modulators of TMEM16A for treating respiratory disease TMEM109, CFTR, TMEM120A ALDH1A1 691/4885MAPT 4472/4885HSD17B10 1113/4885
US-20070010537-A1 Fused pyramidine derivative and use thereof NR5A1, GNRHR, RXFP3 ALDH1A1 1875/4885MAPT 4777/4885HSD17B10 1054/4885
US-20080161302-A1 N-(2-Methoxy-phenyl)-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide; antifungal agents; inhibiting Aspergillus NAT1, CYP1A2, CYP51A1 ALDH1A1 510/4885MAPT 2792/4885HSD17B10 2089/4885
US-11673879-B2 Substituted pyrimidines and methods of use ALK, TYMP, ENTPD5 ALDH1A1 2596/4885MAPT 4712/4885HSD17B10 3723/4885
US-20230399312-A1 SUBSTITUTED PYRIMIDINES AND METHODS OF USE ALK, TYMP, ENTPD5 ALDH1A1 2596/4885MAPT 4712/4885HSD17B10 3723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.