Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | DHODH | Q02127 | 1/20 | 0.65 |
| ▸ | FAAH | O00519 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | UBE2M | P61081 | 1/20 | 0.55 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8401031 | 0.86 | HSD17B1 (0.74) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL11007700 | 0.85 | KMT2A (0.66) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL900311 | 0.84 | MAPT (0.56) | RAB9AMEN1KMT2ANPC1DHODH | |
| SCHEMBL900711 | 0.82 | SCD (0.62) | RAB9AMEN1KMT2ANPC1FAAH | |
| SCHEMBL8405370 | 0.81 | HSD17B1 (0.74) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL31407 | 0.81 | HSD17B1 (0.79) | RAB9AFAAHTP53LMNAHSD17B1 | |
| SCHEMBL24751 | 0.80 | HSD17B1 (0.62) | RAB9AMEN1KMT2ANPC1MAPT | |
| SCHEMBL27623260 | 0.79 | HSD17B1 (0.67) | RAB9AMEN1KMT2ANPC1FAAH | |
| SCHEMBL427929 | 0.79 | TUBB4A (0.72) | RAB9AMEN1KMT2AFAAHMAPT | |
| SCHEMBL4916511 | 0.79 | NPC1 (1.00) | RAB9AMEN1KMT2ANPC1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |