SCHEMBL31078313

SCHEMBL31078313

Cc1cc2cc(Cl)cc(N)c2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 3/20 0.46
CYP3A4 P08684 3/20 0.38
CYP2A6 P11509 1/20 0.37
KEAP1 Q14145 1/20 0.37
CHUK O15111 1/20 0.37
TSHR P16473 2/20 0.32
ALDH1A1 P00352 1/20 0.32
ALOX15 P16050 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
MAP4K1 Q92918 1/20 0.32
HTT P42858 1/20 0.32
TP53 P04637 2/20 0.31
CD44 P16070 1/20 0.31
SLC9A1 P19634 1/20 0.30
CYP1A2 P05177 1/20 0.30
GAA P10253 1/20 0.30
HPGD P15428 1/20 0.30
LMNA P02545 1/20 0.30
NR4A2 P43354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1757169 0.79 HRH4 (0.43) HRH4CYP3A4CHUKTSHRALDH1A1
SCHEMBL14115020 0.79 HRH4 (0.45) HRH4CYP2A6KEAP1ALDH1A1SMN1; SMN2
SCHEMBL1758003 0.76 HRH4 (0.46) HRH4HTTCYP1A2GAAHPGD
SCHEMBL28796378 0.76 CYP2A6 (0.37) CYP3A4CYP2A6KEAP1TSHRMAP4K1
SCHEMBL21235450 0.76 XDH (0.36) HRH4HTTCYP1A2GAAHPGD
SCHEMBL28113979 0.73 HRH4 (0.43) HRH4CYP3A4CYP2A6CHUKTSHR
SCHEMBL28359192 0.71 PDE4A (0.39) CYP2A6KEAP1CHUKALDH1A1ALOX15
SCHEMBL5188098 0.71 AKR1C4 (0.42) HRH4CYP3A4ALDH1A1ALOX15TP53
SCHEMBL17865579 0.71 HRH4 (0.58) HRH4CYP3A4TSHRALDH1A1ALOX15
SCHEMBL8349472 0.70 ALOX15 (0.56) HRH4ALDH1A1ALOX15SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118359634-A Pyrazole derivative and medical use thereof 正大天晴药业集团股份有限公司 2024-07-19 CN disclosed