Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078480 | 0.93 | ROCK2 (0.43) | PIK3CDBTKROCK2HSD11B1KDM1A | |
| SCHEMBL23382311 | 0.84 | ROCK2 (0.40) | PIK3CDBTKROCK2HSD11B1KDM1A | |
| Lithium Ion SCHEMBL31078781 | 0.83 | HSD11B1 (0.42) | PIK3CDBTKROCK2HSD11B1KDM1A | |
| SCHEMBL31078544 | 0.83 | ROCK2 (0.54) | PIK3CDROCK2HSD11B1KDM1AMAOB | |
| SCHEMBL31078511 | 0.78 | L3MBTL1 (0.39) | PIK3CDROCK2HSD11B1L3MBTL1 | |
| SCHEMBL26180337 | 0.76 | PIK3CD (0.51) | PIK3CDBTKKDM1AMAOBCKS1B | |
| SCHEMBL25583498 | 0.75 | ROCK2 (0.54) | ROCK2HSD11B1 | |
| SCHEMBL23587351 | 0.73 | HSD11B1 (0.42) | ROCK2HSD11B1L3MBTL1 | |
| SCHEMBL31078549 | 0.71 | HSD11B1 (0.43) | ROCK2HSD11B1L3MBTL1 | |
| SCHEMBL30800446 | 0.71 | KDM1A (0.42) | PIK3CDBTKKDM1AMAOBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |