Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 7/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.45 |
| ▸ | HTR3B | O95264 | 4/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20854390 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1PARP1HTR3AHRH4 | |
| SCHEMBL5336736 | 0.82 | HTR3A (0.54) | KDM4EALDH1A1PARP1HTR3AHRH4 | |
| Trifluoroacetic Acid SCHEMBL31078693 | 0.82 | HRH4 (0.51) | HSD17B14KDM4EALDH1A1PARP1HTR3A | |
| SCHEMBL9317415 | 0.73 | PRKAB2 (0.47) | KDM4EALDH1A1PARP1HTR3AHRH4 | |
| SCHEMBL31078705 | 0.73 | KDM4E (0.42) | KDM4EALDH1A1TP53LMNA | |
| SCHEMBL2638000 | 0.72 | HTR3A (0.58) | HSD17B14KDM4EALDH1A1PARP1HTR3A | |
| Trifluoroacetic Acid SCHEMBL8801749 | 0.72 | HRH4 (0.49) | KDM4EALDH1A1PARP1HTR3AHRH4 | |
| Hydrochloric Acid SCHEMBL3466386 | 0.71 | HTR3A (0.57) | HSD17B14KDM4EALDH1A1PARP1HTR3A | |
| Trifluoroacetic Acid SCHEMBL3569527 | 0.71 | SIRT6 (0.51) | KDM4EALDH1A1HRH4HRH3MAPT | |
| SCHEMBL12701374 | 0.71 | HTR3A (0.55) | KDM4EALDH1A1HTR3AHRH4HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |