Sugi Predict

Sugi Predict / Compounds / SCHEMBL310860

SCHEMBL310860

SCHEMBL310860

CCCCSc1[c]cccc1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SOAT1 P35610 10/20 0.39
▸ PTGS2 P35354 4/20 0.39
▸ S100A4 P26447 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ RAB9A P51151 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.38
▸ NPSR1 Q6W5P4 3/20 0.38
▸ MAPT P10636 2/20 0.38
▸ TLR8 Q9NR97 1/20 0.37
▸ LMNA P02545 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ MAOA P21397 1/20 0.34
▸ MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL310542 0.94 SOAT1 (0.41) SOAT1PTGS2S100A4NPC1RAB9A
SCHEMBL11111116 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL11483337 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL8930349 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL15844402 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL2452782 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL8943722 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL5495850 0.93 SOAT1 (0.42) SOAT1PTGS2
SCHEMBL310210 0.88 SOAT1 (0.36) SOAT1PTGS2RAB9AALDH1A1MAOA
SCHEMBL11485815 0.84 EPHX2 (0.46) SOAT1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110078652-B Chiral tetraaryl substituted methane and preparation method thereof 香港科技大学深圳研究院 2021-02-12 — — CN claimed
US-8022072-B2 Azolylmethylidenehydrazine derivative and use thereof KAKEN PHARMACEUTICAL CO., LTD. (JP) 2011-09-20 — — US claimed
US-20100317653-A1 OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS ASTRAZENECA AB (SE) 2010-12-16 — — US claimed
US-20100190754-A1 AZOLYLMETHYLIDENEHYDRAZINE DERIVATIVE AND USE THEREOF KAKEN PHARMACEUTICAL CO., LTD. (JP) 2010-07-29 — — US claimed
EP-2168951-A1 AZOLYLMETHYLENEHYDRAZINE DERIVATIVE AND USE THEREOF KAKEN PHARMACEUTICAL CO., LTD. (JP) 2010-03-31 — — EP claimed
US-20080096874-A1 Oxadiazole Derivative as Dgat Inhibitors ASTRAZENECA AB (SE) 2008-04-24 — — US claimed
EP-1833806-A1 OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS AstraZeneca AB (SE) 2007-09-19 — — EP claimed
WO-2006064189-A1 OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS ASTRAZENECA AB (SE) 2006-06-22 — — WO claimed
US-5103006-A Calcium channel activator; inotropic agent E. R. SQUIBB & SONS, INC. (US) 1992-04-07 — — US claimed
CN-109843853-B Composition and method for manufacturing device using the same 东洋合成工业株式会社 2022-09-20 — — CN disclosed
US-11142495-B2 Composition and method for manufacturing device using same TOYO GOSEI CO., LTD. (JP) 2021-10-12 — — US disclosed
EP-3824012-A1 BULK POLYMERISATION OF POLYOXAZOLIDONE BASF SE (DE) 2021-05-26 — — EP disclosed
CN-110078652-B Chiral tetraaryl substituted methane and preparation method thereof 香港科技大学深圳研究院 2021-02-12 — — CN disclosed
US-20200048191-A1 COMPOSITION AND METHOD FOR MANUFACTURING DEVICE USING SAME TOYO GOSEI CO., LTD. (JP) 2020-02-13 — — US disclosed
EP-0048136-A2 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-03-24 — — EP disclosed
US-4319913-A Substituted benzazaphospholes, herbicidal compositions and the use thereof MONSANTO COMPANY (US) 1982-03-16 — — US disclosed
US-4300943-A Ester derivatives of N-arylthio-N-phosphonomethylglycinonitrile MONSANTO COMPANY (US) 1981-11-17 — — US disclosed
US-4252554-A Herbicidal ester derivatives of N-arylthio-N-phosphonomethylglycinonitrile MONSANTO COMPANY (US) 1981-02-24 — — US disclosed
US-4001318-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 — — US disclosed
US-3950367-A FROM IMINO COMPOUND AND PHOSGENE, HERBICIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317653-A1 OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS DGAT1, DGAT2, GPR119 SOAT1 7/4885PTGS2 2375/4885S100A4 4848/4885
US-20200048191-A1 COMPOSITION AND METHOD FOR MANUFACTURING DEVICE USING SAME LBR, LMTK2, MMS19 SOAT1 2111/4885PTGS2 4414/4885S100A4 791/4885
US-11142495-B2 Composition and method for manufacturing device using same LBR, LMTK2, MMS19 SOAT1 2111/4885PTGS2 4414/4885S100A4 791/4885
US-20080096874-A1 Oxadiazole Derivative as Dgat Inhibitors DGAT1, DGAT2, GPR119 SOAT1 7/4885PTGS2 2477/4885S100A4 4841/4885
US-20100190754-A1 AZOLYLMETHYLIDENEHYDRAZINE DERIVATIVE AND USE THEREOF ARSA, AHR, HRH2 SOAT1 3414/4885PTGS2 105/4885S100A4 2453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.