Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | TNKS | O95271 | 5/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31087189 | 0.94 | MAPT (0.50) | MAPTTNKSTNKS2SMN1; SMN2HPGD | |
| SCHEMBL31087165 | 0.71 | HPGD (0.46) | MAPTSMN1; SMN2HPGDPKML3MBTL1 | |
| SCHEMBL23542298 | 0.69 | MAPT (0.61) | MAPTTNKSTNKS2SMN1; SMN2HPGD | |
| SCHEMBL23542291 | 0.68 | MAPT (0.59) | MAPTTNKSTNKS2HPGDPARP1 | |
| SCHEMBL31087172 | 0.67 | HPGD (0.56) | MAPTSMN1; SMN2HPGDPKML3MBTL1 | |
| SCHEMBL31087188 | 0.67 | HPGD (0.59) | MAPTTNKSTNKS2SMN1; SMN2HPGD | |
| SCHEMBL22424056 | 0.66 | CLPP (0.56) | MAPTTNKS2SMN1; SMN2HPGDCLPP | |
| SCHEMBL22423945 | 0.66 | CLPP (0.58) | MAPTTNKSTNKS2SMN1; SMN2HPGD | |
| SCHEMBL31087186 | 0.66 | ALDH1A1 (0.51) | MAPTTNKSTNKS2SMN1; SMN2CLPP | |
| SCHEMBL17476968 | 0.64 | TNKS2 (0.69) | MAPTTNKSTNKS2SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240307394-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR D AND RELATED PRODUCTS AND METHODS | INCYTE CORPORATION | 2024-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240307394-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR D AND RELATED PRODUCTS AND METHODS | MRGPRX1, MRGPRX4, MRGPRX2 | MAPT 3797/4885TNKS 4715/4885TNKS2 4774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.