Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108627 | 0.93 | CYP1A2 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3114532 | 0.89 | NR3C1 (0.37) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3107841 | 0.88 | CYP1A2 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4791642 | 0.85 | NR3C1 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3117913 | 0.85 | DCTPP1 (0.38) | NR3C1 | |
| SCHEMBL3104428 | 0.85 | CYP1A2 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3107937 | 0.85 | CYP1A2 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3112005 | 0.84 | CYP1A2 (0.39) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3109041 | 0.83 | NPBWR1 (0.40) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3098209 | 0.83 | CYP1A2 (0.40) | NR3C1CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256356-A1 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-7723330-B2 | Heterobicyclic pyrazole compounds and methods of use | ARRAY BIOPHARMA INC. (US) | 2010-05-25 | — | — | US | disclosed |
| EP-2001880-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070238726-A1 | Heterobicyclic pyrazole compounds and methods of use | GENENTECH, INC. | 2007-10-11 | — | — | US | disclosed |
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256356-A1 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ROR1, CYP11B1, CYP11B2 | NR3C1 560/4885CYP1A2 254/4885CYP3A4 129/4885 |
| US-20070238726-A1 | Heterobicyclic pyrazole compounds and methods of use | ROR1, CYP11B1, CYP11B2 | NR3C1 560/4885CYP1A2 254/4885CYP3A4 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.