Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31099085 | 0.90 | OPRM1 (0.37) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099059 | 0.90 | OPRM1 (0.37) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099050 | 0.89 | OPRM1 (0.34) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099066 | 0.89 | OPRM1 (0.34) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099020 | 0.86 | OPRM1 (0.33) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099015 | 0.86 | OPRM1 (0.33) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099037 | 0.77 | ROCK2 (0.42) | OPRM1OPRL1LMNAHDAC8P2RX3 | |
| SCHEMBL24854160 | 0.75 | OPRD1 (0.44) | HDAC8ROCK2OPRD1OPRK1 | |
| SCHEMBL31099089 | 0.74 | ROCK2 (0.43) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099039 | 0.73 | ROCK2 (0.41) | OPRM1OPRL1LMNAHDAC8KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |