Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31099085 | 1.00 | OPRM1 (0.37) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099066 | 0.90 | OPRM1 (0.34) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099050 | 0.90 | OPRM1 (0.34) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099010 | 0.90 | OPRM1 (0.36) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099020 | 0.87 | OPRM1 (0.33) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099015 | 0.87 | OPRM1 (0.33) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099091 | 0.81 | ACACB (0.35) | KDM1ABACE1 | |
| SCHEMBL31099037 | 0.79 | ROCK2 (0.42) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL31099089 | 0.75 | ROCK2 (0.43) | OPRM1OPRL1LMNAHDAC8KDM1A | |
| SCHEMBL24854160 | 0.74 | OPRD1 (0.44) | HDAC8ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024255412-A1 | SPIRO HETEROCYCLIC COMPOUND AND USE THEREOF | 广州必贝特医药股份有限公司 | 2024-12-19 | — | — | WO | disclosed |
| CN-118510780-A | Spiro heterocyclic compounds and uses thereof | 广州必贝特医药股份有限公司 | 2024-08-16 | — | — | CN | disclosed |