Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PPIA | P62937 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31107663 | 0.90 | P2RX7 (0.37) | P2RX7PPIATHRBPDK2BTK | |
| SCHEMBL30343966 | 0.76 | CA12 (0.57) | PDK2ALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL25155264 | 0.76 | CA12 (0.57) | PDK2ALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL2741679 | 0.75 | P2RX7 (0.40) | P2RX7PPIAKDM4EALDH1A1HPGD | |
| SCHEMBL31360270 | 0.75 | PPIA (0.36) | PPIAPDK2KIT | |
| SCHEMBL25155384 | 0.75 | PPIA (0.36) | PPIAPDK2KIT | |
| SCHEMBL13162913 | 0.75 | CA12 (0.58) | PDK2CA12CA1CA2CA9 | |
| SCHEMBL16491275 | 0.74 | SMN1; SMN2 (0.42) | PPIAKDM4EALDH1A1CA12CA1 | |
| SCHEMBL25155684 | 0.73 | AAK1 (0.43) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL25155742 | 0.73 | AAK1 (0.43) | KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024215817-A1 | NOVEL 5-CYCLOPROYLQUINOLINE DERIVATIVES AS PLPRO INHIBITORS | PFIZER INC. (US) | 2024-10-17 | — | — | WO | disclosed |