Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | PPIA | P62937 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 5/20 | 0.33 |
| ▸ | CA2 | P00918 | 5/20 | 0.33 |
| ▸ | CA9 | Q16790 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31107651 | 0.90 | P2RX7 (0.38) | P2RX7PPIANPC1RAB9ABTK | |
| SCHEMBL29135649 | 0.78 | P2RX7 (0.36) | P2RX7PPIAATRMAPTKDM4E | |
| SCHEMBL31583140 | 0.77 | ATR (0.42) | P2RX7PPIAATR | |
| SCHEMBL25155339 | 0.76 | CA12 (0.56) | MAPTHPGDPDK2CA12CA1 | |
| SCHEMBL30344719 | 0.76 | CA12 (0.56) | MAPTHPGDPDK2CA12CA1 | |
| SCHEMBL13162402 | 0.75 | CA12 (0.57) | CYP2C19PDK2CA12CA1CA2 | |
| SCHEMBL2741679 | 0.74 | P2RX7 (0.40) | P2RX7PPIANPC1RAB9AMAPT | |
| SCHEMBL31360270 | 0.74 | PPIA (0.36) | PPIAPDK2KIT | |
| SCHEMBL25155384 | 0.74 | PPIA (0.36) | PPIAPDK2KIT | |
| SCHEMBL25155900 | 0.73 | MTNR1A (0.43) | ATRCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024215817-A1 | NOVEL 5-CYCLOPROYLQUINOLINE DERIVATIVES AS PLPRO INHIBITORS | PFIZER INC. (US) | 2024-10-17 | — | — | WO | disclosed |