Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31111660 | 0.86 | KMO (0.59) | HRH3MAP4K4CLK4CDK2CDC7 | |
| SCHEMBL31112078 | 0.78 | MAPK14 (0.47) | MAP4K4CLK4CDK2CDC7ROCK2 | |
| SCHEMBL1199430 | 0.76 | BMPR1A (0.49) | KCNH2PIM1PIM3PIM2ACVR1 | |
| SCHEMBL8226204 | 0.74 | BMPR1A (0.40) | CDK2KCNH2PIM1PIM3PIM2 | |
| Hydrochloric Acid SCHEMBL3267673 | 0.74 | KCNH2 (0.54) | CLK4ROCK2KMOKCNH2CHUK | |
| SCHEMBL31485227 | 0.74 | TBK1 (0.42) | MAP4K4CLK4CDK2CDC7ROCK2 | |
| SCHEMBL31106272 | 0.73 | HRH3 (0.52) | HRH3MAP4K4CLK4CDK2CDC7 | |
| SCHEMBL8220996 | 0.72 | POLB (0.50) | CDK2 | |
| SCHEMBL31106276 | 0.72 | HRH3 (0.51) | HRH3MAP4K4CLK4CDK2CDC7 | |
| SCHEMBL29493726 | 0.72 | ALDH1A1 (0.61) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |