Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adamantaneacetic Acid SCHEMBL6865701 | 0.85 | ALDH1A1 (0.62) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| Adamantaneacetic Acid SCHEMBL24688608 | 0.85 | ALDH1A1 (0.62) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| Adamantaneacetic Acid SCHEMBL306081 | 0.85 | ALDH1A1 (0.62) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| SCHEMBL9948726 | 0.85 | POLB (0.50) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| SCHEMBL16684403 | 0.85 | ALDH1A1 (0.46) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| SCHEMBL5354981 | 0.84 | ALDH1A1 (0.39) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| Adamantaneacetic Acid SCHEMBL4147939 | 0.83 | ALDH1A1 (0.60) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| SCHEMBL13766697 | 0.80 | SMN1; SMN2 (0.46) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 | |
| SCHEMBL17628790 | 0.80 | — | — | |
| SCHEMBL10820607 | 0.78 | POLB (0.44) | ALDH1A1POLBCYP3A4CYP2C19HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222417-B2 | Compound having 11β-HSD1 inhibitory activity | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20100179325-A1 | COMPOUND HAVING 11BETA-HSD1 INHIBITORY ACTIVITY | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-07-15 | — | — | US | disclosed |
| EP-2172453-A1 | COMPOUND HAVING 11 ß-HSD1 INHIBITORY ACTIVITY | Taisho Pharmaceutical Co. Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179325-A1 | COMPOUND HAVING 11BETA-HSD1 INHIBITORY ACTIVITY | HSD11B1, CYP4A11, HSD11B2 | ALDH1A1 289/4885POLB 3958/4885CYP3A4 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.