Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684403 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| SCHEMBL3112462 | 0.80 | ALDH1A1 (0.49) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| Adamantaneacetic Acid SCHEMBL24688608 | 0.78 | ALDH1A1 (0.62) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| Adamantaneacetic Acid SCHEMBL306081 | 0.78 | ALDH1A1 (0.62) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| Adamantaneacetic Acid SCHEMBL6865701 | 0.78 | ALDH1A1 (0.62) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| SCHEMBL9948726 | 0.77 | POLB (0.50) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| SCHEMBL16940693 | 0.76 | HSD11B1 (0.39) | SMN1; SMN2NPSR1ALDH1A1TSHRHSD11B1 | |
| Adamantaneacetic Acid SCHEMBL4147939 | 0.76 | ALDH1A1 (0.60) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB | |
| SCHEMBL13126733 | 0.75 | ALDH1A1 (0.43) | SMN1; SMN2NPSR1ALDH1A1TSHRMEN1 | |
| SCHEMBL17317458 | 0.74 | HSD11B1 (0.45) | SMN1; SMN2NPSR1ALDH1A1TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324265-B2 | Heterocyclic compounds having type I 11β hydroxysteroid dehydrogenase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-12-04 | — | — | US | disclosed |
| US-20090170832-A1 | HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| US-20090131491-A1 | ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I | SHIONOGI & CO., LTD. (JP) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131491-A1 | ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I | HSD3B1, NR5A1, HSD11B1 | SMN1; SMN2 4090/4885NPSR1 1626/4885ALDH1A1 203/4885 |
| US-20090170832-A1 | HETEROCYCLIC COMPOUNDS HAVING TYPE I 11beta HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY | HSD17B1, HSD11B1, HSD3B1 | SMN1; SMN2 3709/4885NPSR1 651/4885ALDH1A1 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.