Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BPTF | Q12830 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160738 | 0.85 | ALDH1A1 (0.43) | ALDH1A1P2RX7HSD11B1HSD11B2BPTF | |
| SCHEMBL3112462 | 0.85 | ALDH1A1 (0.49) | POLBALDH1A1P2RX7HSD11B1HSD11B2 | |
| Adamantaneacetic Acid SCHEMBL24688608 | 0.82 | ALDH1A1 (0.62) | POLBALDH1A1P2RX7HSD11B1CYP3A4 | |
| Adamantaneacetic Acid SCHEMBL6865701 | 0.82 | ALDH1A1 (0.62) | POLBALDH1A1P2RX7HSD11B1CYP3A4 | |
| Adamantaneacetic Acid SCHEMBL306081 | 0.82 | ALDH1A1 (0.62) | POLBALDH1A1P2RX7HSD11B1CYP3A4 | |
| SCHEMBL16684403 | 0.81 | ALDH1A1 (0.46) | POLBALDH1A1P2RX7HSD11B1HSD11B2 | |
| Adamantaneacetic Acid SCHEMBL4147939 | 0.80 | ALDH1A1 (0.60) | POLBALDH1A1P2RX7HSD11B1CYP3A4 | |
| SCHEMBL13766697 | 0.77 | SMN1; SMN2 (0.46) | POLBALDH1A1P2RX7HSD11B1HSD11B2 | |
| SCHEMBL17628790 | 0.77 | — | — | |
| Adamantaneacetic Acid SCHEMBL6531436 | 0.77 | POLB (0.58) | POLBALDH1A1P2RX7CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104903290-A | Novel compound having ability to inhibit 11beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient | AHN GOOK PHARMACEUTICAL CO LTD | 2015-09-09 | — | — | CN | disclosed |
| US-8536173-B2 | Tetrahydroquinoxaline urea derivatives as modulators of 11-B-hydroxysteroid dehydrogenase type I | SANOFI (FR) | 2013-09-17 | — | — | US | disclosed |
| US-20120165337-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165337-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | NR2C2, CBR3, NR0B2 | POLB 1979/4885ALDH1A1 2230/4885P2RX7 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.