Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 8/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26121769 | 1.00 | AGTR2 (0.44) | AGTR2EPHX2ATMFOLH1 | |
| SCHEMBL21132251 | 0.85 | AGTR2 (0.41) | AGTR2EPHX2ATMFOLH1 | |
| SCHEMBL15690421 | 0.85 | MMP2 (0.39) | AGTR2EPHX2 | |
| SCHEMBL5070456 | 0.84 | AGTR2 (0.34) | AGTR2EPHX2 | |
| SCHEMBL949815 | 0.82 | AGTR2 (0.39) | AGTR2 | |
| SCHEMBL7318416 | 0.82 | AGTR2 (0.39) | AGTR2FOLH1 | |
| SCHEMBL2203146 | 0.82 | AGTR2 (0.39) | AGTR2 | |
| SCHEMBL6847951 | 0.82 | AGTR2 (0.39) | AGTR2 | |
| SCHEMBL6847947 | 0.82 | AGTR2 (0.39) | AGTR2 | |
| SCHEMBL949817 | 0.82 | AGTR2 (0.39) | AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906516-B2 | Carbonyl compounds | MERCK PATENT GMBH (DE) | 2011-03-15 | — | — | US | disclosed |
| US-20100256131-A1 | CARBONYL COMPOUNDS | TSAKLAKIDIS CHRISTOS | 2010-10-07 | — | — | US | disclosed |
| US-20080003214-A1 | Medicaments Comprising Carbonyl Compounds, And The Use Thereof | MERCK PATENT GMBH (DE) | 2008-01-03 | — | — | US | disclosed |
| US-20060183739-A1 | Carbonyl compounds | MERCK PATENT GMBH (DE) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256131-A1 | CARBONYL COMPOUNDS | F2, F11, PDHX | AGTR2 1987/4885EPHX2 395/4885ATM 1479/4885 |
| US-20080003214-A1 | Medicaments Comprising Carbonyl Compounds, And The Use Thereof | F2, PDHX, SDHB | AGTR2 2031/4885EPHX2 236/4885ATM 2985/4885 |
| US-20060183739-A1 | Carbonyl compounds | F2, F11, PDHX | AGTR2 1987/4885EPHX2 395/4885ATM 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.