Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31144872 | 0.77 | KDM4E (0.56) | POLBKDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL31144950 | 0.75 | MAPT (0.41) | POLBKDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL31144951 | 0.74 | LMNA (0.40) | POLBKDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL848265 | 0.73 | POLB (0.44) | POLBPKMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL31144864 | 0.73 | MEN1 (0.49) | POLBKDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL30632281 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2ATMNPC1 | |
| SCHEMBL17008860 | 0.68 | ALDH1A1 (0.35) | POLBKDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL31437774 | 0.65 | ALDH1A1 (0.49) | POLBALDH1A1PKMMAPK1ATM | |
| SCHEMBL24728704 | 0.63 | L3MBTL1 (0.47) | POLBALDH1A1PKMSMN1; SMN2MAPK1 | |
| SCHEMBL22576442 | 0.63 | SMN1; SMN2 (0.50) | POLBKDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024175804-A1 | NUCLEAR TRANSPORT MODULATORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-08-29 | — | — | WO | disclosed |