Sugi Predict

Sugi Predict / Compounds / SCHEMBL31146157

SCHEMBL31146157

SCHEMBL31146157

C[C@H](NC(=O)Cc1cc2c(C#N)c(O)ccc2[nH]c1=O)c1ccc(F)cc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR139 Q6DWJ6 4/20 0.39
▸ HSD17B10 Q99714 3/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ CTSK P43235 1/20 0.35
▸ CTSC P53634 1/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ IDH1 O75874 1/20 0.34
▸ ANO1 Q5XXA6 1/20 0.34
▸ CXCR2 P25025 2/20 0.34
▸ PIK3CD O00329 2/20 0.33
▸ GSK3B P49841 1/20 0.33
▸ ADORA2B P29275 1/20 0.33
▸ ADORA1 P30542 1/20 0.33
▸ PIK3CG P48736 1/20 0.33
▸ NEK1 Q96PY6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31146064 0.89 IDH1 (0.42) GPR139HSD17B10KDM4EALDH1A1KMT2A
SCHEMBL31145923 0.84 GPR139 (0.36) GPR139HSD17B10KDM4EMEN1KMT2A
SCHEMBL31146058 0.80 GPR139 (0.42) GPR139HSD17B10KDM4EALDH1A1IDH1
SCHEMBL31146050 0.79 GPR139 (0.42) GPR139HSD17B10KDM4EALDH1A1IDH1
SCHEMBL31145976 0.79 GPR139 (0.39) GPR139HSD17B10KDM4EALDH1A1MEN1
SCHEMBL31145932 0.78 GPR139 (0.41) GPR139HSD17B10KDM4EALDH1A1RAB9A
SCHEMBL31146046 0.78 GPR139 (0.40) GPR139HSD17B10KDM4EALDH1A1IDH1
SCHEMBL31146104 0.77 GPR139 (0.40) GPR139HSD17B10KDM4EALDH1A1IDH1
SCHEMBL31146018 0.76 GPR139 (0.39) GPR139HSD17B10KDM4EALDH1A1IDH1
SCHEMBL31146119 0.74 KDM4E (0.46) GPR139HSD17B10KDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688748-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2026-02-11 — — EP disclosed
US-20260008774-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2026-01-08 — — US disclosed
US-12448369-B2 Quinolinone amide compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-10-21 — — US disclosed
US-20250026740-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. 2025-01-23 — — US disclosed
WO-2024206339-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2024-10-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12448369-B2 Quinolinone amide compounds and uses thereof TNNI3, TNNT2, COQ8A GPR139 4135/4885HSD17B10 505/4885KDM4E 3988/4885
US-20250026740-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, COQ8A GPR139 4135/4885HSD17B10 505/4885KDM4E 3988/4885
US-20260008774-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF TNNT2, TNNI3, TNNC1 GPR139 4225/4885HSD17B10 940/4885KDM4E 4379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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