Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.44 |
| ▸ | GRM5 | P41594 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25489474 | 1.00 | MET (0.44) | METGRM5TP53HDAC1RXFP1 | |
| SCHEMBL30420051 | 0.91 | MET (0.47) | METGRM5TP53HDAC1RXFP1 | |
| SCHEMBL25415557 | 0.91 | MET (0.47) | METGRM5TP53HDAC1RXFP1 | |
| SCHEMBL31150561 | 0.90 | MET (0.37) | METGRM5TP53 | |
| SCHEMBL25485800 | 0.90 | MET (0.37) | METGRM5TP53 | |
| SCHEMBL25488483 | 0.84 | MET (0.47) | METGRM5TP53HDAC1RXFP1 | |
| SCHEMBL25489375 | 0.82 | MET (0.39) | METGRM5TP53HDAC1RXFP1 | |
| SCHEMBL25489125 | 0.80 | TP53 (0.44) | METTP53HDAC1 | |
| SCHEMBL25525670 | 0.78 | MET (0.60) | METGRM5TP53HDAC1NPSR1 | |
| SCHEMBL25489376 | 0.78 | MET (0.43) | METGRM5TP53HDAC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240336609-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. | 2024-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240336609-A1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | IL6, IL1B, IL1A | MET 4212/4885GRM5 1379/4885TP53 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.