SCHEMBL31159781

SCHEMBL31159781

COC(=O)c1cc(NC[C@@H]2CCO2)c(N)c(OC(F)F)c1

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.43
▸ KMT2A Q03164 5/20 0.39
▸ PTGER4 P35408 2/20 0.38
▸ PDE4D Q08499 4/20 0.36
▸ PDE4A P27815 2/20 0.36
▸ PDE4B Q07343 2/20 0.36
▸ PDE4C Q08493 2/20 0.36
▸ HCAR3 P49019 1/20 0.36
▸ MEN1 O00255 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 2/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ KDM4E B2RXH2 3/20 0.34
▸ HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27176929 0.88 KDM4E (0.42) ALDH1A1KMT2APTGER4MEN1MAPT
SCHEMBL31321908 0.85 KMT2A (0.37) ALDH1A1KMT2APTGER4HCAR3MEN1
SCHEMBL30966520 0.85 ALDH1A1 (0.47) ALDH1A1KMT2APTGER4MEN1MAPT
SCHEMBL31159929 0.84 KMT2A (0.36) ALDH1A1KMT2APTGER4HCAR3MEN1
SCHEMBL31159702 0.84 KMT2A (0.36) ALDH1A1KMT2APTGER4PDE4DPDE4A
SCHEMBL31159788 0.84 HCAR3 (0.42) ALDH1A1KMT2AHCAR3MEN1MAPT
SCHEMBL25279173 0.83 KMT2A (0.40) ALDH1A1KMT2APTGER4HCAR3MEN1
SCHEMBL31463429 0.83 KMT2A (0.40) ALDH1A1KMT2APTGER4HCAR3MEN1
SCHEMBL25404705 0.83 KMT2A (0.40) ALDH1A1KMT2APTGER4HCAR3MEN1
SCHEMBL24901946 0.83 PTGER4 (0.43) ALDH1A1KMT2APTGER4HCAR3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688144-A1 COMPOUNDS AS GLP-1R AGONISTS Terns Pharmaceuticals, Inc. (US) 2026-02-11 — — EP disclosed
WO-2024206878-A1 COMPOUNDS AS GLP-1R AGONISTS TERNS PHARMACEUTICALS, INC. (US) 2024-10-03 — — WO disclosed
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