Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.32 |
| ▸ | HK1 | P19367 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116165 | 0.91 | HPGD (0.36) | MAPTHPGDALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL3075736 | 0.86 | CA2 (0.37) | MAPTALDH1A1MEN1KMT2APKM | |
| SCHEMBL3085696 | 0.81 | HPGD (0.46) | MAPTHPGDALDH1A1SMN1; SMN2USP2 | |
| Trifluoromethanesulfonic Acid SCHEMBL5094785 | 0.76 | GRIA1 (0.39) | MAPTALDH1A1MEN1KMT2APKM | |
| SCHEMBL13144458 | 0.75 | ALDH1A1 (0.42) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL3065870 | 0.75 | HPGD (0.43) | MAPTHPGDALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL4012568 | 0.75 | MAPT (0.41) | MAPTHPGDALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL6993736 | 0.73 | MEN1 (0.41) | MAPTALDH1A1MEN1KMT2APKM | |
| Trifluoromethanesulfonic Acid SCHEMBL9420028 | 0.72 | KIF11 (0.38) | MAPTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL10432083 | 0.71 | KIF11 (0.43) | MAPTHPGDALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144893-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137816-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-11-13 | — | — | WO | disclosed |