Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PTPRC | P08575 | 3/20 | 0.40 |
| ▸ | S100A4 | P26447 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10432083 | 0.90 | KIF11 (0.43) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL5094785 | 0.88 | GRIA1 (0.39) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| SCHEMBL3075736 | 0.85 | CA2 (0.37) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| SCHEMBL13144458 | 0.84 | ALDH1A1 (0.42) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL9420028 | 0.83 | KIF11 (0.38) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| SCHEMBL13327363 | 0.82 | S100A4 (0.38) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| SCHEMBL13304950 | 0.82 | S100A4 (0.38) | MEN1KMT2AMAPTKIF11ALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL9419957 | 0.76 | CASP6 (0.40) | MEN1KMT2AMAPTKIF11PTPRC | |
| SCHEMBL204674 | 0.74 | TSHR (0.46) | MEN1KMT2AMAPTALDH1A1PTPRC | |
| SCHEMBL3088067 | 0.71 | MAPT (0.50) | MEN1KMT2AMAPTALDH1A1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779281-B1 | ISOXAZOLES | SANKYO CO (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6096771-A | ISOXAZOLE DERIVATIVES EXHIBITING EXCELLENT TYPE B AND TYPE A MONOAMINE OXIDASE INHIBITORY ACTIVITIES, THEREFORE USEFUL FOR PREVENTING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5965591-A | MONOAMINE OXIDASE INHIBITOR; FOR PROPHYLAXIS AND TREATING PARKINSON'S DISEASE, DEPRESSION AND ALZHEIMER'S DISEASE | SANKYO COMPANY, LIMITED (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0779281-A1 | ISOXAZOLES | SANKYO COMPANY LIMITED (JP) | 1997-06-18 | — | — | EP | disclosed |