Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31168685 | 0.86 | EGFR (0.48) | EGFRKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL31168657 | 0.86 | TTR (0.45) | KDM4EKMT2ASMN1; SMN2TTRAPP | |
| SCHEMBL31168468 | 0.74 | AKR1C3 (0.40) | KDM4EKMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL15744783 | 0.72 | KDM4E (0.41) | KDM4EKMT2ASMN1; SMN2TTRAPP | |
| SCHEMBL31168612 | 0.71 | KDM4E (0.41) | EGFRKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31168605 | 0.70 | TTR (0.45) | KDM4EKMT2ASMN1; SMN2TTRAPP | |
| SCHEMBL31168603 | 0.70 | AGBL2 (0.42) | EGFRKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3310811 | 0.63 | NFE2L2 (0.47) | KDM4EKMT2ASMN1; SMN2TTRAPP | |
| SCHEMBL125390 | 0.62 | KDM4E (0.40) | EGFRKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18911298 | 0.62 | ALDH1A1 (0.42) | KDM4ETDP1ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024216164-A1 | N2-((5-HYDROXY)-2-PYRIDYL)-PYRIDINE-2,4-DIAMINE DERIVATIVES AS EHMT1/2 MODULATORS FOR THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2024-10-17 | — | — | WO | disclosed |