Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT7 | O95251 | 8/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 8/20 | 0.41 |
| ▸ | KAT6B | Q8WYB5 | 7/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 6/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172566 | 0.79 | HTT (0.49) | PDE4BMAPTGAAMEN1KMT2A | |
| SCHEMBL31172651 | 0.78 | LMNA (0.42) | KAT7KAT6APDE4BMAPTGAA | |
| SCHEMBL9953859 | 0.78 | MAPT (0.38) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL188678 | 0.75 | GRM5 (0.38) | MAPTGAAALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL28825607 | 0.75 | GAA (0.47) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31172576 | 0.74 | HTR2A (0.46) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31172601 | 0.74 | HTT (0.37) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL23704452 | 0.72 | RAB9A (0.37) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL1578005 | 0.72 | DPP4 (0.44) | PDE4BMAPTGAAALDH1A1NPSR1 | |
| SCHEMBL23704445 | 0.71 | ALDH1A1 (0.36) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4680226-A2 | ACYLSULFONAMIDE KAT6A INHIBITORS | Olema Pharmaceuticals, Inc. (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20260015327-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS INC (US) | 2026-01-15 | — | — | US | disclosed |
| US-12428379-B2 | Acylsulfonamide KAT6A inhibitors | OLEMA PHARMACEUTICALS, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| US-20250136553-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS, INC. | 2025-05-01 | — | — | US | disclosed |
| WO-2024189598-A2 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS, INC. (US) | 2024-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136553-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | KAT6A, KAT2A, KAT6B | KAT7 5/4885KAT6A 1/4885KAT6B 3/4885 |
| US-12428379-B2 | Acylsulfonamide KAT6A inhibitors | KAT6A, KAT2A, KAT6B | KAT7 5/4885KAT6A 1/4885KAT6B 3/4885 |
| US-20260015327-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | KAT6A, KAT2A, KAT6B | KAT7 4/4885KAT6A 1/4885KAT6B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.