SCHEMBL31738784

SCHEMBL31738784

COC(=O)c1cc2c(cc1CBr)OC1(CCN(C(=O)OC(C)(C)C)CC1)CO2

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 11/20 0.42
▸ PKM P14618 1/20 0.40
▸ IDO1 P14902 2/20 0.39
▸ GPR183 P32249 1/20 0.37
▸ HRH3 Q9Y5N1 1/20 0.36
▸ JAK2 O60674 1/20 0.35
▸ JAK1 P23458 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31024717 0.90 GPR119 (0.43) GPR119PKMIDO1GPR183HRH3
SCHEMBL31024719 0.86 PKM (0.42) GPR119PKMIDO1GPR183HRH3
SCHEMBL31024681 0.86 PKM (0.42) GPR119PKMIDO1GPR183HRH3
SCHEMBL31024669 0.84 GPR119 (0.40) GPR119PKMIDO1GPR183HRH3
SCHEMBL26135023 0.84 PKM (0.41) GPR119PKMGPR183JAK2JAK1
SCHEMBL30591662 0.84 PKM (0.41) GPR119PKMGPR183JAK2JAK1
SCHEMBL31192103 0.79 PKM (0.42) GPR119PKMJAK2JAK1
SCHEMBL31738792 0.79 PKM (0.42) GPR119PKMJAK2JAK1
SCHEMBL25345030 0.76 EED (0.36) GPR119PKMIDO1GPR183HRH3
SCHEMBL31024668 0.76 EED (0.36) GPR119PKMIDO1GPR183HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 — — EP disclosed
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