Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 3/20 | 0.42 |
| ▸ | MC5R | P33032 | 3/20 | 0.42 |
| ▸ | MC3R | P41968 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937764 | 0.88 | RAB9A (0.43) | RAB9ANPC1MC4RMC5RMC3R | |
| SCHEMBL3127386 | 0.83 | GABRA1 (0.45) | RAB9ANPC1ALOX5GABRA1GABRG2 | |
| SCHEMBL3115322 | 0.80 | MC4R (0.52) | RAB9ANPC1MC4RMC5RMC3R | |
| SCHEMBL3119512 | 0.79 | RAB9A (0.53) | RAB9ANPC1MC4RMC5RMC3R | |
| SCHEMBL3129331 | 0.79 | MEN1 (0.42) | POLBGABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL30644739 | 0.71 | HDAC1 (0.54) | NPC1BCHEALOX5CAMK2DMEN1 | |
| SCHEMBL3121013 | 0.71 | ALDH1A1 (0.40) | BCHEACHEKMT2A | |
| SCHEMBL3119104 | 0.70 | MAPT (0.55) | NPC1BCHEACHEMEN1KMT2A | |
| SCHEMBL3131170 | 0.70 | GABRA1 (0.43) | RAB9ANPC1GABRA1GABRG2GABRB3 | |
| SCHEMBL23518692 | 0.69 | EPHX1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |