Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 4/20 | 0.52 |
| ▸ | MC5R | P33032 | 4/20 | 0.52 |
| ▸ | MC3R | P41968 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119512 | 0.95 | RAB9A (0.53) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL7937764 | 0.80 | RAB9A (0.43) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3119504 | 0.80 | RAB9A (0.43) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3262320 | 0.76 | RAB9A (0.47) | RAB9ANPC1GABRA1GABRG2GABRB3 | |
| SCHEMBL3942077 | 0.75 | RAB9A (0.55) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3129331 | 0.75 | MEN1 (0.42) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL3942488 | 0.75 | RAB9A (0.49) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3118297 | 0.75 | MC4R (0.48) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3118314 | 0.75 | MC4R (0.48) | MC4RMC5RMC3RRAB9ANPC1 | |
| SCHEMBL3120950 | 0.74 | ALDH1A1 (0.40) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |