Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 1/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301042 | 0.98 | IP6K1 (0.59) | IP6K1MYCNR4A1AVPR2MEN1 | |
| SCHEMBL15923351 | 0.97 | MYC (0.57) | IP6K1MYCNR4A1AVPR2MEN1 | |
| SCHEMBL15123245 | 0.86 | IP6K1 (0.66) | IP6K1MEN1KMT2AMRGPRX4TSHR | |
| SCHEMBL5063205 | 0.86 | AVPR2 (0.54) | IP6K1AVPR2MEN1KMT2AATM | |
| SCHEMBL2088694 | 0.85 | ACLY (0.57) | MYCNR4A1MEN1KMT2ATSHR | |
| SCHEMBL14080465 | 0.85 | ADRB1 (0.63) | IP6K1MYCNR4A1TSHRCASP1 | |
| SCHEMBL15923279 | 0.85 | RAB9A (0.56) | IP6K1MYCNR4A1AVPR2TSHR | |
| SCHEMBL3823637 | 0.84 | KDM4E (0.58) | IP6K1MYCNR4A1AVPR2MRGPRX4 | |
| Hydrochloric Acid SCHEMBL4890076 | 0.84 | ACLY (0.56) | MYCNR4A1MEN1KMT2ACASP1 | |
| Hydrochloric Acid SCHEMBL15929282 | 0.84 | ADRB1 (0.61) | IP6K1MYCNR4A1TSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2022-07-19 | — | — | US | disclosed |
| US-11161858-B2 | Boron-containing small molecules as antiprotozoal agents | ANACOR PHARMACEUTICALS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| EP-3694840-B1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2020-09-24 | — | — | US | disclosed |
| EP-3694840-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | Hoffmann-La Roche AG (CH) | 2020-08-19 | — | — | EP | disclosed |
| US-20200247828-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, LLC | 2020-08-06 | — | — | US | disclosed |
| CN-111247129-A | Piperazine derivatives as MAGL inhibitors | 豪夫迈·罗氏有限公司 | 2020-06-05 | — | — | CN | disclosed |
| US-10669291-B2 | Boron-containing small molecules as antiprotozoal agents | ANACOR PHARMACEUTICALS, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190135837-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, LLC | 2019-05-09 | — | — | US | disclosed |
| WO-2019072785-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2019-04-18 | — | — | WO | disclosed |
| EP-1813603-A1 | AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH | Kissei Pharmaceutical Co., Ltd. (JP) | 2007-08-01 | — | — | EP | disclosed |
| US-7169772-B2 | 4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2007-01-30 | — | — | US | disclosed |
| US-20050004103-A1 | 4,4-Difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivatives or salts thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1445253-A1 | 4,4-DIFLUORO-1, 2, 3, 4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-08-11 | — | — | EP | disclosed |
| EP-0877736-B1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMA CO LTD (JP) | 2004-04-21 | — | — | EP | disclosed |
| CN-1104419-C | Benzazepine derivatives with vasopressin agonistic activity | OTSUKA PHARMA CO LTD (JP) | 2003-04-02 | — | — | CN | disclosed |
| US-6096736-A | Benzazepine derivatives with vasopressin agonistic activity | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2000-08-01 | — | — | US | disclosed |
| CN-1209121-A | Benzazepine Derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-02-24 | — | — | CN | disclosed |
| EP-0877736-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997022591-A1 | BENZAZEPINE DERIVATIVES WITH VASOPRESSIN AGONISTIC ACTIVITY | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247828-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | BTD, BAD, BRI3BP | IP6K1 1907/4885MYC 2241/4885NR4A1 4097/4885 |
| US-11390610-B2 | Piperazine derivatives as MAGL inhibitors | MAGI3, PYM1, MAG | IP6K1 2564/4885MYC 1970/4885NR4A1 4749/4885 |
| US-11161858-B2 | Boron-containing small molecules as antiprotozoal agents | BTD, BAD, BRI3BP | IP6K1 1907/4885MYC 2241/4885NR4A1 4097/4885 |
| US-20190135837-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | BTD, BAD, BRI3BP | IP6K1 1907/4885MYC 2241/4885NR4A1 4097/4885 |
| US-10669291-B2 | Boron-containing small molecules as antiprotozoal agents | BTD, BAD, BRI3BP | IP6K1 1907/4885MYC 2241/4885NR4A1 4097/4885 |
| US-20200299277-A1 | PIPERAZINE DERIVATIVES AS MAGL INHIBITORS | MAGI3, PYM1, MAG | IP6K1 2564/4885MYC 1970/4885NR4A1 4749/4885 |
| US-20050004103-A1 | 4,4-Difluoro-1,2,3,4-tetrahydro-5h-1-benzazepine derivatives or salts thereof | AVPR2, AVPR1B, AVPR1A | IP6K1 2505/4885MYC 2785/4885NR4A1 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.