Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31196421 | 1.00 | AKR1C3 (0.45) | AKR1C3AKR1C1KDM4BKDM5CKDM5B | |
| SCHEMBL4173650 | 0.85 | PROKR1 (0.48) | KDM4BKDM5CKDM5BPROKR1OPRK1 | |
| SCHEMBL31196254 | 0.84 | OPRM1 (0.40) | KDM4BKDM5CKDM5BPROKR1OPRK1 | |
| SCHEMBL29050696 | 0.75 | JAK2 (0.44) | KDM4BKDM5CKDM5BPROKR1DDB1 | |
| SCHEMBL16094504 | 0.74 | KDM4C (0.53) | KDM4BKDM5CKDM5BPROKR1HDAC3 | |
| SCHEMBL30504055 | 0.74 | KDM4C (0.53) | KDM4BKDM5CKDM5BPROKR1HDAC3 | |
| SCHEMBL6118725 | 0.73 | PRKD1 (0.45) | KDM4BKDM5CKDM5BDDB1CRBN | |
| SCHEMBL31196335 | 0.73 | RIPK1 (0.49) | KDM5BPROKR1GSK3BHDAC4PARP10 | |
| SCHEMBL6494259 | 0.72 | PROKR1 (0.50) | KDM5CKDM5BPROKR1GSK3BHDAC3 | |
| SCHEMBL18230111 | 0.71 | OPRM1 (0.47) | KDM4BKDM5CKDM5BPROKR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709716-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233554-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |