Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KDM6B | O15054 | 2/20 | 0.37 |
| ▸ | KDM5C | P41229 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30504055 | 0.87 | KDM4C (0.53) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL16094504 | 0.87 | KDM4C (0.53) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL4173650 | 0.85 | PROKR1 (0.48) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL25984345 | 0.85 | PROKR1 (0.48) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| Nitrous Acid SCHEMBL29117354 | 0.81 | KDM4C (0.47) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL16445734 | 0.81 | KDM4E (0.58) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL16055561 | 0.80 | KMO (0.53) | PROKR1KDM4CKDM4AKMOKDM5A | |
| SCHEMBL30379389 | 0.80 | KDM4C (0.50) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL26087368 | 0.80 | KDM4C (0.50) | PROKR1HDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL29211039 | 0.79 | PROKR1 (0.43) | PROKR1HDAC4HDAC3HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6946463-B2 | 1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain | ASTRAZENECA AB (SE) | 2005-09-20 | — | — | US | disclosed |
| US-20040053929-A1 | 1, 2, 5, 10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain | ASTRAZENECA AB (SE) | 2004-03-18 | — | — | US | disclosed |
| EP-1325004-A1 | 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-B]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002026741-A1 | 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2002-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053929-A1 | 1, 2, 5, 10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain | OPRD1, OPRK1, ACHE | PROKR1 4836/4885HDAC4 2115/4885HDAC3 973/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.