Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPRB | P23467 | 1/20 | 0.33 |
| ▸ | PTPRE | P23469 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69690 | 0.84 | KEAP1 (0.47) | KEAP1NAPRTKDM4EGAAMAPT | |
| SCHEMBL27820698 | 0.84 | CNR2 (0.42) | KEAP1NAPRTKDM4EGAAMAPT | |
| SCHEMBL2080349 | 0.80 | KDM4E (0.51) | KDM4EGAAMAPTALDH1A1CYP1A2 | |
| SCHEMBL30590698 | 0.79 | KEAP1 (0.33) | KEAP1NAPRTKDM4EGAAMAPT | |
| SCHEMBL5653478 | 0.77 | KEAP1 (0.41) | KEAP1NAPRTKDM4EGAAMAPT | |
| SCHEMBL14837183 | 0.76 | ALDH1A1 (0.61) | MAPTALDH1A1KMT2AHPGDTDP1 | |
| SCHEMBL27820699 | 0.73 | NR4A2 (0.43) | KDM4EGAAMAPTALDH1A1ALOX15 | |
| SCHEMBL29042806 | 0.72 | RAB9A (0.41) | KEAP1NAPRTKDM4EGAAMAPT | |
| SCHEMBL69393 | 0.71 | NR4A2 (0.44) | KDM4EGAAALDH1A1HSD17B10CA12 | |
| SCHEMBL13272035 | 0.69 | KMT2A (0.55) | KDM4EMAPTALDH1A1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653048-B2 | Prodrugs based on gemcitabine structure and synthetic methods and applications thereof | SANLUGEN PHARMATECH LTD. (CN) | 2014-02-18 | — | — | US | claimed |
| US-20120088908-A1 | Prodrugs Based on Gemcitabine Structure and Synthetic Methods and Applications Thereof | SANLUGEN PHARMATECH LTD. (CN) | 2012-04-12 | — | — | US | claimed |
| EP-2423215-A1 | PRODRUGS BASED ON GEMCITABINE STRUCTURE AS WELL AS SYNTHETIC METHOD AND APPLICATION THEREOF | Sanlugen Pharmatech Ltd. (CN) | 2012-02-29 | — | — | EP | claimed |
| US-8653048-B2 | Prodrugs based on gemcitabine structure and synthetic methods and applications thereof | SANLUGEN PHARMATECH LTD. (CN) | 2014-02-18 | — | — | US | disclosed |
| US-20120088908-A1 | Prodrugs Based on Gemcitabine Structure and Synthetic Methods and Applications Thereof | SANLUGEN PHARMATECH LTD. (CN) | 2012-04-12 | — | — | US | disclosed |
| EP-2423215-A1 | PRODRUGS BASED ON GEMCITABINE STRUCTURE AS WELL AS SYNTHETIC METHOD AND APPLICATION THEREOF | Sanlugen Pharmatech Ltd. (CN) | 2012-02-29 | — | — | EP | disclosed |
| US-8093349-B2 | Terminally modified polybranched polyimide, metal-plated terminally modified polybranched polyimide, and method for producing the same | UBE INDUSTRIES, LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| US-20100009206-A1 | TERMINALLY MODIFIED POLYBRANCHED POLYIMIDE, METAL-PLATED TERMINALLY MODIFIED POLYBRANCHED POLYIMIDE, AND METHOD FOR PRODUCING THE SAME | UBE INDUSTRIES, LTD. (JP) | 2010-01-14 | — | — | US | disclosed |
| US-5770340-A | USING ELECTROGRAPHIC PRINTING PLATE HAVING ELECTROCONDUCTIVE SUPPORT WITH PHOTOCONDUCTIVE LAYER CONTAINING INORGANIC PHOTOCONDUCTOR, SPECIFIC SENSITIZING DYE AND BINDER, ALSO WITH BACKING HAVING LOW ELECTRICAL RESISTANCE | FUJI PHOTO FILM CO., LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5677098-A | USING CYANINE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088908-A1 | Prodrugs Based on Gemcitabine Structure and Synthetic Methods and Applications Thereof | TYMP, DCTD, GLS2 | KEAP1 4836/4885NAPRT 671/4885KDM4E 2472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.