Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31200193 | 0.77 | MMP12 (0.56) | BRD4MMP12APPMEN1POLB | |
| SCHEMBL12925129 | 0.77 | MMP12 (0.56) | BRD4MMP12APPMEN1POLB | |
| SCHEMBL1150521 | 0.74 | BRD4 (0.42) | BRD4MMP12APPMEN1POLB | |
| SCHEMBL12896064 | 0.73 | BRD4 (0.41) | BRD4MMP12APPMEN1POLB | |
| SCHEMBL27927096 | 0.71 | ALDH1A1 (0.52) | BRD4MMP12APPPOLBPIK3C3 | |
| SCHEMBL14856794 | 0.69 | PIK3C3 (0.42) | BRD4MMP12APPPIK3C3 | |
| SCHEMBL25469530 | 0.69 | GABRA1 (0.39) | BRD4MMP12APPMEN1POLB | |
| SCHEMBL12526800 | 0.68 | BRD4 (0.44) | BRD4MMP12APPMAPK1PIK3C3 | |
| SCHEMBL586478 | 0.68 | BRD4 (0.51) | BRD4MMP12APPMAPK1PIK3C3 | |
| SCHEMBL21611607 | 0.67 | KDR (0.39) | BRD4MMP12APPMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709722-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233547-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |