Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21611498 | 0.81 | ALDH1A1 (0.42) | KDRMMP12BRD4MEN1KMT2A | |
| SCHEMBL21611579 | 0.78 | MMP12 (0.36) | MMP12DRD1BRD4MKNK1APP | |
| SCHEMBL12925129 | 0.77 | MMP12 (0.56) | KDRMMP12BRD4MEN1POLB | |
| SCHEMBL31200193 | 0.77 | MMP12 (0.56) | KDRMMP12BRD4MEN1POLB | |
| SCHEMBL21611401 | 0.72 | LMNA (0.53) | KDRMEN1POLBMAPK1KMT2A | |
| SCHEMBL21611558 | 0.72 | KDM4E (0.44) | KDRDRD1MEN1KMT2AMKNK1 | |
| SCHEMBL21858763 | 0.71 | TRPA1 (0.50) | TRPA1MEN1POLBKMT2A | |
| SCHEMBL21611495 | 0.71 | CYP1A1 (0.44) | KDRMEN1POLBKMT2A | |
| SCHEMBL21611512 | 0.70 | MAP4K4 (0.48) | TRPA1KMT2ATTBK1TTBK2 | |
| SCHEMBL21611480 | 0.69 | SMN1; SMN2 (0.56) | KDRMEN1KMT2ATTBK1TTBK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210221785-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | VERNALIS (R&D) LTD (GB) | 2021-07-22 | — | — | US | disclosed |
| EP-3818054-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2021-05-12 | — | — | EP | disclosed |
| CN-112368276-A | Amino-pyrimidinone derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2021-02-12 | — | — | CN | disclosed |
| WO-2020008013-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2020-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210221785-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DHFR, QDPR, DPYD | KDR 1079/4885MMP12 4819/4885TRPA1 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.