Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Sarafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.94 |
| ▸ | LMNA | P02545 | 5/20 | 0.94 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.94 |
| ▸ | HPGD | P15428 | 4/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | TOP2A | P11388 | 4/20 | 0.63 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sarafloxacin SCHEMBL311593 | 0.98 | ALDH1A1 (0.98) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Sarafloxacin SCHEMBL379212 | 0.97 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| Sarafloxacin SCHEMBL23392485 | 0.96 | ALDH1A1 (0.98) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9443539 | 0.91 | ALDH1A1 (0.85) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9443495 | 0.91 | ALDH1A1 (0.85) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9443455 | 0.90 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9443514 | 0.90 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9443509 | 0.90 | ALDH1A1 (0.80) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL9044286 | 0.90 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAHSD17B10HPGD | |
| SCHEMBL11017466 | 0.90 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12191133-B2 | Mass spectrometry method for identifying and/or authenticating a sample | ORVINUM AG (CH) | 2025-01-07 | — | — | US | disclosed |
| CN-117517491-A | Method for detecting veterinary drug residues in animal-derived food | 宁夏菲杰特检测有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-116466000-A | Method for rapidly determining 176 PPCPs content in source water | 福建省产品质量检验研究院(福建省缺陷产品召回技术中心) | 2023-07-21 | — | — | CN | disclosed |
| CN-115707968-A | Method for detecting 5 types of 17 antibiotics in pork | 上海市环境科学研究院 | 2023-02-21 | — | — | CN | disclosed |
| US-20220199389-A1 | A MASS SPECTROMETRY METHOD FOR IDENTIFYING AND/OR AUTHENTICATING A SAMPLE | ORVINUM AG (CH) | 2022-06-23 | — | — | US | disclosed |
| EP-3966571-A1 | A MASS SPECTROMETRY METHOD FOR IDENTIFYING AND/OR AUTHENTICATING A SAMPLE | Orvinum AG (CH) | 2022-03-16 | — | — | EP | disclosed |
| WO-2020229346-A1 | A MASS SPECTROMETRY METHOD FOR IDENTIFYING AND/OR AUTHENTICATING A SAMPLE | ORVINUM AG (CH) | 2020-11-19 | — | — | WO | disclosed |
| EP-2576778-B1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN RODENTS | UNIV KYOTO (JP) | 2017-08-09 | — | — | EP | disclosed |
| CN-103969383-B | The assay method of fluoroquinolone antibiotics in a kind of cosmetics | 中国检验检疫科学研究院 | 2016-08-24 | — | — | CN | disclosed |
| US-9273364-B2 | Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms | KYOTO UNIVERSITY (JP) | 2016-03-01 | — | — | US | disclosed |
| CN-103969383-A | Method for testing fluoroquinolones antibiotics in cosmetics | CHINESE ACAD INSP & QUARANTINE | 2014-08-06 | — | — | CN | disclosed |
| US-20130137099-A1 | TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS | KYOTO UNIVERSITY (JP) | 2013-05-30 | — | — | US | disclosed |
| US-8093381-B2 | Method of synthesis of fluoroquinolones | BIOCODEX (FR) | 2012-01-10 | — | — | US | disclosed |
| EP-2138490-B1 | New method for synthesis of fluoroquinolones | BIOCODEX (FR) | 2011-08-31 | — | — | EP | disclosed |