SCHEMBL31207397

SCHEMBL31207397

Fc1cc(COc2cccc(OC3CCCC3)n2)c(Cl)cc1Br

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 9/20 0.40
SCN9A Q15858 2/20 0.34
GLP1R P43220 2/20 0.34
LOX P28300 1/20 0.33
LOXL2 Q9Y4K0 1/20 0.33
KDM1A O60341 2/20 0.33
KDM1B Q8NB78 2/20 0.33
AXL P30530 1/20 0.32
FLT3 P36888 1/20 0.32
MERTK Q12866 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31207479 0.84 SCN9A (0.45) FFAR4SCN9AGLP1R
SCHEMBL31207461 0.81 ACACB (0.36) FFAR4SCN9AKDM1AKDM1B
SCHEMBL31207456 0.81 RXRA (0.40) KDM1AKDM1B
SCHEMBL31207369 0.81 SCN9A (0.46) FFAR4SCN9AGLP1R
SCHEMBL31207450 0.79 HDAC6 (0.37) FFAR4SCN9AGLP1R
SCHEMBL15536664 0.74 SCN9A (0.54) SCN9AKDM1AKDM1B
SCHEMBL31207421 0.71 NR4A2 (0.40) FFAR4SCN9A
SCHEMBL31207401 0.70 GRM5 (0.38)
SCHEMBL26971185 0.67 HTR7 (0.41) SCN9AGLP1R
SCHEMBL30232727 0.66 GLP1R (0.50) GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4702021-A1 COMPOUNDS CAPABLE OF MODULATING GPR65 Pathios Therapeutics Limited (GB) 2026-03-04 EP disclosed
WO-2024224064-A1 COMPOUNDS CAPABLE OF MODULATING GPR65 Pathios Therapeutics Limited (GB) 2024-10-31 WO disclosed