Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10215485 | 0.88 | HPGD (0.59) | TNKSAKR1C3AKR1C2AKR1C1HPGD | |
| SCHEMBL312120 | 0.83 | TNKS (0.53) | TNKSAKR1C3AKR1C2AKR1C1HPGD | |
| SCHEMBL312749 | 0.80 | TNKS (0.55) | TNKSAKR1C3AKR1C2AKR1C1HPGD | |
| SCHEMBL6747772 | 0.80 | KDM4E (0.59) | TNKSHPGDKDM4EMEN1KMT2A | |
| SCHEMBL312252 | 0.79 | AKR1B1 (0.46) | TNKSHPGDKDM4ECYP3A4MEN1 | |
| SCHEMBL311129 | 0.79 | HPGD (0.63) | TNKSAKR1C3AKR1C2AKR1C1HPGD | |
| SCHEMBL312740 | 0.79 | AKR1B1 (0.57) | TNKSHPGDKDM4ECYP3A4MEN1 | |
| SCHEMBL312410 | 0.79 | CYP3A4 (0.52) | HPGDKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL311402 | 0.76 | ATM (0.53) | HPGDKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL311828 | 0.75 | CYP2D6 (0.46) | HPGDKDM4ECYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |