Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312410 | 0.91 | CYP3A4 (0.52) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL312740 | 0.91 | AKR1B1 (0.57) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL10215485 | 0.87 | HPGD (0.59) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL311334 | 0.84 | EGFR (0.46) | HPGDKDM4EALDH1A1KMT2AGAA | |
| SCHEMBL312442 | 0.84 | BACE1 (0.62) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL311402 | 0.84 | ATM (0.53) | HPGDKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL311828 | 0.83 | CYP2D6 (0.46) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL311962 | 0.80 | EGFR (0.47) | HPGDKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL312029 | 0.80 | HPGD (0.47) | AKR1B1HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL311784 | 0.80 | AKR1B1 (0.46) | AKR1B1HPGDKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |