Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.31 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25171636 | 1.00 | LMNA (0.33) | LMNAMAPK1NR1D1NR1H3ALDH1A1 | |
| SCHEMBL30893303 | 0.82 | NPSR1 (0.38) | LMNANR1D1ALDH1A1MAPTHTT | |
| SCHEMBL23540991 | 0.82 | NPSR1 (0.38) | LMNANR1D1ALDH1A1MAPTHTT | |
| SCHEMBL25168509 | 0.81 | LMNA (0.35) | LMNAMAPK1NR1D1NR1H3ALDH1A1 | |
| SCHEMBL30893241 | 0.80 | MAPT (0.36) | LMNAMAPK1NR1D1ALDH1A1MAPT | |
| SCHEMBL30936620 | 0.80 | ALDH1A1 (0.44) | LMNAALDH1A1MAPTHTTCYP2D6 | |
| SCHEMBL25174512 | 0.78 | KMT2A (0.34) | LMNAMAPK1ALDH1A1MAPTHTT | |
| SCHEMBL31720604 | 0.75 | TDP1 (0.46) | LMNAMAPK1ALDH1A1MAPTHTT | |
| SCHEMBL20045660 | 0.74 | ALDH1A1 (0.34) | LMNAMAPK1NR1D1ALDH1A1MAPT | |
| SCHEMBL30936632 | 0.74 | NPSR1 (0.38) | LMNANR1D1ALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974035-A | 2-Aminoimidazole derivatives as PRMT5 inhibitors | 米拉蒂医疗股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-4426690-A2 | 2-AMINO IMIDAZOLE DERIVATIVES AS PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |