SCHEMBL31222079

SCHEMBL31222079

Cc1cccc(NC(=O)c2cn(-c3nccs3)nc2C)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.51
KDM4E B2RXH2 2/20 0.51
MAPT P10636 2/20 0.51
LMNA P02545 2/20 0.51
NPC1 O15118 6/20 0.50
RAB9A P51151 6/20 0.50
KMT2A Q03164 5/20 0.50
MEN1 O00255 4/20 0.50
HSD17B10 Q99714 2/20 0.50
TP53 P04637 2/20 0.50
NFKB1 P19838 1/20 0.50
NFKB2 Q00653 1/20 0.50
RELA Q04206 1/20 0.50
SMN1; SMN2 Q16637 8/20 0.47
HPGD P15428 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
HTT P42858 2/20 0.44
DRD4 P21917 1/20 0.44
PLK4 O00444 1/20 0.44
MAP4K4 O95819 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31222126 0.89 RAB9A (0.50) ALDH1A1MAPTLMNANPC1RAB9A
SCHEMBL31222093 0.89 KDM1A (0.46) MAPTLMNANPC1RAB9AKMT2A
SCHEMBL31222083 0.88 SMN1; SMN2 (0.48) ALDH1A1KDM4EMAPTLMNANPC1
SCHEMBL31222100 0.88 KDM5B (0.47) ALDH1A1KDM4EMAPTLMNANPC1
SCHEMBL31222127 0.83 ALDH1A1 (0.47) ALDH1A1KDM4EMAPTLMNANPC1
SCHEMBL31222128 0.80 LMNA (0.50) ALDH1A1KDM4EMAPTLMNANPC1
SCHEMBL31222080 0.80 RAB9A (0.46) ALDH1A1KDM4EMAPTLMNANPC1
SCHEMBL31222111 0.78 GAA (0.46) ALDH1A1KDM4EMAPTNPC1RAB9A
SCHEMBL31222086 0.77 RAB9A (0.44) KDM4EMAPTNPC1RAB9AHSD17B10
SCHEMBL31222109 0.77 LMNA (0.48) ALDH1A1KDM4EMAPTLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118994136-A Pyrazole compound containing N1-heterocycle, and preparation method and application thereof 安阳师范学院 2024-11-22 CN disclosed