Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228488 | 0.96 | P2RX7 (0.41) | P2RX7L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL31228552 | 0.92 | P2RX7 (0.42) | P2RX7L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL31228678 | 0.89 | MMP13 (0.37) | P2RX7MEN1KMT2ANPSR1CCR5 | |
| SCHEMBL31228306 | 0.89 | MMP13 (0.40) | P2RX7MEN1KMT2ACCR5 | |
| SCHEMBL31228300 | 0.89 | MMP13 (0.40) | P2RX7MEN1KMT2ACCR5 | |
| SCHEMBL31228368 | 0.86 | MAPT (0.40) | L3MBTL1MEN1MAPTKMT2AGHSR | |
| SCHEMBL31228239 | 0.84 | MMP13 (0.39) | P2RX7L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL31228513 | 0.84 | P2RX7 (0.44) | P2RX7L3MBTL1MEN1MAPTKMT2A | |
| SCHEMBL31228367 | 0.84 | MMP13 (0.40) | P2RX7MEN1KMT2ACCR5 | |
| SCHEMBL31228376 | 0.83 | MMP13 (0.38) | P2RX7MEN1KMT2APOLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |