Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228374 | 0.92 | P2RX7 (0.42) | P2RX7PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31228488 | 0.91 | P2RX7 (0.41) | P2RX7MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL31228427 | 0.89 | MMP13 (0.37) | P2RX7MCL1NR1H2NR1H3MEN1 | |
| SCHEMBL31228513 | 0.87 | P2RX7 (0.44) | P2RX7CA1CA2MEN1MAPT | |
| SCHEMBL31228420 | 0.85 | TACR1 (0.42) | NR1H2NR1H3MEN1MAPTKMT2A | |
| SCHEMBL31228678 | 0.81 | MMP13 (0.37) | P2RX7NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL31228300 | 0.81 | MMP13 (0.40) | P2RX7MEN1KMT2A | |
| SCHEMBL31228306 | 0.81 | MMP13 (0.40) | P2RX7MEN1KMT2A | |
| SCHEMBL31228440 | 0.80 | AGTR2 (0.40) | MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL31228239 | 0.79 | MMP13 (0.39) | P2RX7MEN1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |