Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
| ▸ | MMP7 | P09237 | 3/20 | 0.32 |
| ▸ | MMP9 | P14780 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 3/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228678 | 0.94 | MMP13 (0.37) | MMP13KMT2AMEN1GPR119P2RX7 | |
| SCHEMBL31228367 | 0.93 | MMP13 (0.40) | MMP13KMT2AMEN1GPR119P2RX7 | |
| SCHEMBL31228306 | 0.87 | MMP13 (0.40) | MMP13KMT2AMEN1GPR119P2RX7 | |
| SCHEMBL31228300 | 0.87 | MMP13 (0.40) | MMP13KMT2AMEN1GPR119P2RX7 | |
| SCHEMBL31228374 | 0.83 | P2RX7 (0.42) | KMT2AMEN1P2RX7POLBCCR5 | |
| SCHEMBL31228362 | 0.83 | MMP3 (0.31) | KMT2AHCRTR2MMP3 | |
| SCHEMBL31228189 | 0.83 | MMP3 (0.31) | KMT2AHCRTR2MMP3 | |
| SCHEMBL31228509 | 0.83 | MMP3 (0.31) | KMT2AHCRTR2MMP3 | |
| SCHEMBL31228239 | 0.82 | MMP13 (0.39) | MMP13KMT2AMEN1GPR119P2RX7 | |
| SCHEMBL31153712 | 0.81 | MMP13 (0.37) | MMP13KMT2AMEN1GPR119P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |