Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228540 | 0.92 | MEN1 (0.39) | MEN1MAPTKMT2APARP1ABCB1 | |
| SCHEMBL31228420 | 0.89 | TACR1 (0.42) | MEN1MAPTKMT2APARP1ABCB1 | |
| SCHEMBL31228320 | 0.86 | TACR1 (0.43) | MEN1MAPTKMT2APARP1JAK2 | |
| SCHEMBL31228368 | 0.83 | MAPT (0.40) | MEN1MAPTKMT2APARP1GHSR | |
| SCHEMBL31228393 | 0.82 | KLK7 (0.44) | MEN1MAPTKMT2APARP1GHSR | |
| SCHEMBL31228526 | 0.81 | TACR1 (0.42) | MEN1MAPTKMT2APARP1JAK2 | |
| SCHEMBL31228552 | 0.80 | P2RX7 (0.42) | MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL31153839 | 0.79 | JAK2 (0.46) | MEN1MAPTKMT2APARP1JAK2 | |
| SCHEMBL31153754 | 0.79 | JAK2 (0.46) | MEN1MAPTKMT2APARP1JAK2 | |
| SCHEMBL23342685 | 0.77 | MEN1 (0.51) | MEN1MAPTKMT2AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |