⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228575 | 0.91 | MEN1 (0.33) | — | |
| SCHEMBL31228327 | 0.86 | — | — | |
| SCHEMBL31228414 | 0.84 | KMT2A (0.32) | — | |
| SCHEMBL31228472 | 0.82 | HSD17B10 (0.33) | — | |
| SCHEMBL31228346 | 0.80 | HSD17B10 (0.34) | — | |
| SCHEMBL31153653 | 0.77 | NR1H2 (0.30) | — | |
| SCHEMBL31228241 | 0.76 | YAP1 (0.39) | — | |
| SCHEMBL31228509 | 0.75 | MMP3 (0.31) | — | |
| SCHEMBL31228362 | 0.75 | MMP3 (0.31) | — | |
| SCHEMBL31228189 | 0.75 | MMP3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |