Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120624 | 0.83 | ADORA2B (0.41) | ADORA1ADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL3114995 | 0.82 | ADORA1 (0.44) | ADORA1ADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL837101 | 0.81 | ADORA2B (0.55) | ADORA1ADORA2B | |
| SCHEMBL3114286 | 0.81 | ADORA1 (0.48) | ADORA1ADORA2B | |
| SCHEMBL836626 | 0.81 | ADORA2B (0.59) | ADORA1ADORA2B | |
| SCHEMBL3113964 | 0.81 | ADORA1 (0.41) | ADORA1ADORA2BSIRT1SIRT3SIRT5 | |
| SCHEMBL3119933 | 0.81 | ADORA1 (0.49) | ADORA1ADORA2B | |
| SCHEMBL836484 | 0.81 | ADORA2B (0.57) | ADORA1ADORA2B | |
| SCHEMBL837123 | 0.81 | ADORA2B (0.50) | ADORA1ADORA2B | |
| SCHEMBL835824 | 0.80 | ADORA2B (0.44) | ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | ADORA1 32/4885ADORA2B 111/4885SIRT1 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.